To perform the assay of Chlorpromazine hydrochloride.

 Experiment

1. Object:
2. Structure:
3. Properties:
4. Category: 
5. Theory:
6. Description: 
7. Assay:
8. Factor: 
9. Reference:

Object:

To perform the assay of Chlorpromazine hydrochloride.

 

Structure:

Properties:

Molecular Formula: C17H19CIN2S, HCI

Mol. Wt.: 355.3

Chlorpromazine hydrochloride contains not less than 99.0 per cent and not more than

101.0 percent of C17H19CINZS, HCI, calculated on dried basis.

Category: 

Antipsychotic, antiemetic.

Theory:

Dose: As antipsychotic, orally, 75 to 300 mg daily, in divided doses; by intramuscular

injection, 25 to 50 mg. As antiemetic, orally, 10 to 25 mg every 4 to 6 hours; by deep

intramuscular injection, 25 mg initially followed by 25 mg-50 mg every 3 to 4 hours until necessary.

Description: 

A white or creamy-white, crystalline powder, odourless. It decomposes on exposure to air and light becoming yellow, pink and finally violet.

Assay:

• Weigh accurately about 0.6 g, dissolve in 200 ml of acetone and add 15 ml of mercuric acetate solution.
• Titrate with 0.1 M perchloric acid, using a saturated solution of methyl orange in acetone as an indicator.
• Carry out a blank titration.

Factor: 

1 ml of 0.1 M perchloric acid is equivalent to 0.03553 g of C17H19CIN2S, HCI.

Storage: Store protected from light and moisture.

Reference:

Dr. Abhishek Tiwari, Dr. Rajeev Kumar " A practical book of medicinal chemistry" Nirali Prakashan Pune 2019 pp 61-62