To perform synthesis of Pyrazole from Chalcone.

 Experiment

Synthesis of 1,3-diphenylpyrazole from phenylhydrazine and ethyl-acetoacetate.

Object: 

To perform the synthesis of Pyrazole from chalcone.

Reference:

Vogel's Textbook of Practical Organic Chemistry by Brain and Furniss, 5th edition, Longmann and Technical N.Y. pp- 1180.

Requirements:

Glassware: Beaker,funnel, pippett, china dish etc

Chemical: Phenylhydrazine, ethylaceto-acetate, ether,

Instruments: water bath.

Theory:

Pyrazole is a heterocyclic compound characterized by 5 member ring of 3 carbon atoms and 2 adjacent nitrogen atoms. The notable drugs contains pyrazole ring are clecoxib and anabolic steroid stanozolol.

Uses of  Pyrazole derivative:

The pyrazole derivatives are  widely used fungicide, insecticide, and herbicides including clorfenapyr,fenopyroximate, fipronil.

Procedure:

1. In a clean china dish ,take 36.5 ml of phenylhydrazine and 49 ml of ethylacetoacetate.
2. Then stirr well both content.
3. Heat the china dish over water bath for 2 hrs, with continues stirring.
4. Then again heat the china dish further for 1 hr on water bath.
5. Then add 2 ml of ether and left it for a day.
6. On another day take off the solid product with the help of glasrod/ spatula and filter the product.

Calculation:

Find out theoretical yield and practical yield.

Then from these two values find out the percentage yield.

Percentage yield = practical yield. ×100

                                 theoretical yield

Result:

 The product was synthesized and the percentage yield was found to be____%.