To perform the assay of Ibuprofen as per I.P.

 Experiment

Aim: 

To perform the assay of Ibuprofen as per Indian Pharmacopeia.

Reference:

Indian Pharmacopoeia 2010, Gov. of India, Ministry of Health and Family welfare, Delhi, India pp-1480.

Requirements:

Chemical: ibuprofen,ethanol,NaOH, Phenolphthalein.

Glassware: beaker, burette, pipette, funnel, conical flask.

Theory:

Ibuprofen is a medication of nonsteriodal anti-infflammatory drug class. It is used for treating pain, fever, and inflammation. 

IUPAC Name:

 (RS)-2-(4- isobutylphenyl) propionic acid

Chemical  formula :

 C13H18O2

Molar Mass: 206.29 g/mol

Catagory:

 Anti- inflammatory, Analgesic

Dose: 600mg-1.2gm daily in divided dose.

Procedure:

1. Weight accurately 0.4 g of Ibuprofen.
2. Dissolve it in 100 ml of ethanol (95%)
3. And titrate with 0.1M NaOH using 0.2ml of phenolphthalein solution as indicator.
4. Also carry out blank titration.
5. 1ml of 0.1M NaOH  is equivalent to 0.02063 of C13H18O2 (Ibuprofen).

Result: 

The assay of Ibuprofen was successfully perfomed.